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  April 28, 1999    RECOMMENDATION:    BUY

Cypress Bioscience, Inc.   (NASDAQ: CYPB)

"CYPB Announces Sale of Prosorba Manufacturing Facility, and Exercise of Warrants - $10.4 Million in Total Proceeds; Reiterating BUY Recommendation"

Market Data:


Exchange Symbol.......................CYPB (NASDAQ)
Price of Common Stock (04/27/99)..............$3.81
30-Day Average Trading Volume...............279,000
Shares Outstanding...........................39.5mm
52-Week High/Low........................$4.15/$1.43
CYPB Corporate Information:


Address...............4350 Executive Drive, Suite 325
.................................San Diego, CA  92121
Telephone/Fax.............619-452-2323 / 619-452-1212
Chairman & CEO............Jay D. Kranzler, M.D., Ph.D.
President & COO.........................Carl Bobkoski

Recent Developments


Over the past ten days, CYPB has made two significant announcements that we believe position the Company's stock for further upward movement. The two events, the sale of the manufacturing facility and the exercise of warrants (discussed in detail below) resulted in proceeds of approximately $10.4 million to the Company. From a financial perspective, we believe these events put CYPB on a more solid financial footing. But more importantly, we believe the early exercise of the purchase option reflects Fresenius' positive view of the prospects for the Prosorba column within the rheumatoid arthritis (RA) market. CYPB management also believes that Fresenius' ownership of the facility will accelerate the manufacturing scale-up, facilitate the ramp-up in marketing, and shorten the timeframe for CYPB to reach profitability. We reiterate our BUY recommendation for investors tolerant of risks associated with small-cap investments.

April 27th Announcement: CYPB announced that Fresenius AG, its global partner in the manufacturing and marketing of the Prosorba column, had exercised an option to purchase the Prosorba manufacturing facilities from CYPB. The option was granted earlier this year as part of the partnering agreements between the two companies, and was exercisable until the end of 2000. Total proceeds to CYPB, a portion of which was previously drawn down in the form of an interest-free line of credit, was approximately $5.2 million. We believe the early exercise of this option by Fresenius is a very positive development for CYPB, as it reflects Fresenius' positive views on the prospects for the Prosorba column in the RA market, should accelerate manufacturing and marketing activities, and could result in a shortened timeframe to profitability for CYPB.

April 21St Announcement: CYPB announced that approximately 2.6 million outstanding publicly traded warrants had been exercised, resulting in proceeds to CYPB of approximately $5.2 million. Approximately 200,000 warrants that were not exercised were redeemed by CYPB at ten cents per warrant on April 19, 1999. Again, we feel this is a very positive development for CYPB. It not only provides additional capital to support the commercialization ramp-up of Prosorba, but also provides additional financial flexibility with respect to other development programs and/or financing plans.

  For Additional Information


Contact SmallCaps Online LLC-- 212-554-4158

  Risk Considerations


This section of the document is to remind potential investors to undertake a prudent level of due diligence prior to making an investment in securities of Cypress Bioscience, Inc. For a complete description of risks and uncertainties to CYPB's business, see the Risk Factors section in CYPB's SEC filings, which can be accessed directly from the SEC Edgar filings at www.SEC.gov on the internet. Other potential risks include:

  • Market risk: Like many small-cap and micro-cap stocks, CYPB's share price is trading near its 52-week low. Investors should consider technical risks common to many small-cap or micro-cap stock investments, including liquidity levels, small float, risk of dilution, dependence on key personnel, and dependence on single products or technologies.
  • Business risk: CYPB has limited experience in the marketing of the Prosorba column for the RA indication. Although it is seeking a corporate partner to assist in marketing of Prosorba for RA, there can be no assurance that such an alliance will materialize, or that the market will accept the product.
  • Competitive risk: There are many new drugs in development targeting the RA indication, and we anticipate the competition to be intense. Many of CYPB's competitors may be larger, better capitalized and hold dominant market positions.

Sources for Additional Information


The following are website addresses offering related information, and links to other sources of information.

www.CypressBio.com CYPB's corporate website

www.SmallCapsOnline.com SmallCaps Online's site for company information and research

www.FDA.gov  US Food and Drug Administration homepage

www.rheumatology.org American College of Rheumatology homepage

www.arthritis.org  Arthritis Foundation homepage

www.WHO.int  World Health Organization homepage

www.AABB.org  American Association of Blood Banks homepage

www.AMA-Assn.org  American Medical Association homepage

www.SEC.gov  U.S. Securities and Exchange Commission, with links to EDGAR filings

 

The information in this report has been obtained from sources which we believe to be reliable, but we do not guarantee its accuracy or completeness. Neither the information nor any opionion expressed constitutes a solicitation by SmallCaps Online LLC for the purchase or sale of any securities. SmallCaps Online LLC has performed investment banking, consulting or other services for and may solicit investment banking, consulting or other business from, any company mentioned in this report. SmallCaps Online LLC or persons associated with SmallCaps Online LLC may at anytime be long or short any of the securities referred to herein and may make purchases or sales thereof while this report is in circulation or posted on the SmallCaps Online LLC website at www.SmallCapsOnline.com. This material, or any portion thereof, may not be reproduced without prior permission from SmallCaps Online LLC. SmallCaps Online LLC is not responsible for the contents of this document which is intended for electronic transmission and could be thus subjected to tampering or alteration. Copyright © 1999 by SmallCaps Online LLC. All rights reserved.